ISIM is a Department under SUND at KU that researches in microbiology and immunology. We would like quantitative measurements of cell activity by the interaction between bacteria and human cells as well as bacteria exposed to antibiotics. This is to elucidate new treatments for infections. This has previously only been possible with expression analysis but with the CalScreener we can measure directly on the cells over time. The CalScreener instrument is a so-called “multi-channel isothermal calorimetric system” that measures heat generation by metabolic activity of cells.